Quick Answer: What Should You Not Take With Clopidogrel?

Does clopidogrel affect blood pressure?

Arterial hypertension is associated with platelet activation, increased sCD40L levels and endothelial dysfunction suggesting that inhibition of platelet-derived sCD40L release may improve endothelial function and lower blood pressure (BP)..

What can you not take with clopidogrel?

Clopidogrel may interact with other medicationsDiabetes drug. In most cases, repaglinide should not be taken with clopidogrel. … Stomach acid drugs (proton pump inhibitors) … Nonsteroidal anti-inflammatory drugs (NSAIDs) … Blood thinners.Drugs used to treat depression. … Salicylates (aspirin) … Opioids.

What drugs interact with clopidogrel?

Serious InteractionsSELECTED PLATELET AGGREGATION INHIBITORS/NSAIDS.CLOPIDOGREL/ESOMEPRAZOLE; OMEPRAZOLE; CIMETIDINE.CLOPIDOGREL/FLUCONAZOLE; KETOCONAZOLE; VORICONAZOLE.CLOPIDOGREL/ETRAVIRINE.CLOPIDOGREL/FELBAMATE.CLOPIDOGREL/TICLOPIDINE.CLOPIDOGREL/FLUOXETINE; FLUVOXAMINE.More items…

Can you take vitamin D with clopidogrel?

No interactions were found between clopidogrel and Vitamin D3. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Can clopidogrel cause leg pain?

You may have muscle pain while you’re taking Plavix. It’s not known for sure why this occurs in people taking the drug. If you have severe muscle pain while you’re taking Plavix, call your doctor right away. They can check to see what’s causing your discomfort, and they’ll recommend whether you need medical treatment.

How do you know if clopidogrel is working?

You may notice that you bruise or bleed more easily and it will take longer to stop bleeding while you are taking clopidogrel. This shows that clopidogrel is working. However, if bleeding is excessive, prolonged, or you notice blood in your urine or stool, seek urgent medical advice.

Is there an alternative to clopidogrel?

1). Besides oral anticoagulants, such as warfarin and the more recent dabigatran[9], and niche agents, such as cilostazol and ticlopidine[10,11], the most promising alternatives to clopidogrel in those with background aspirin therapy are prasugrel and ticagrelor.

Can I drink coffee with clopidogrel?

Conclusions: Acute caffeine administration after clopidogrel loading appears to be associated with enhanced platelet inhibition 2 to 4 hours after clopidogrel intake. The mechanism probably involves synergistic increase in cAMP levels.

Does clopidogrel cause stomach problems?

Easy bleeding/bruising, stomach upset/pain, diarrhea, and constipation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Although unlikely, serious bleeding in the stomach, gut, eyes, or brain may occur.

What time of day is best to take clopidogrel?

You can take clopidogrel at whatever time of day you find easiest to remember, but take your doses at the same time of day each day. Most people prefer to take it in the morning, as they find this helps them to remember to take it regularly. You can take the tablet either before or after a meal.

How long should you take clopidogrel for?

The new recommendation is that after 12 months if there is no evidence of major bleeding or other problems with clopidogrel + aspirin, it is suggested you continue that therapy for an additional 18 months. I know, it seems long.

Is it safe to take omeprazole with clopidogrel?

The FDA, MHRA and EMA discourage use of omeprazole and esomeprazole in patients taking clopidogrel. There is insufficient evidence regarding which PPI is least likely to interact.

Does clopidogrel affect the liver?

The severity of liver injury associated with clopidogrel ranges from transient, mild serum enzyme elevations to clinically apparent acute hepatitis that can be severe and lead to death. Most cases resolve with drug withdrawal within 1 to 3 months.

What painkillers are safe to take with clopidogrel?

Painkillers. It’s fine to take paracetamol with clopidogrel. You can also take opioid-type painkillers such as codeine, co-codamol, tramadol or morphine alongside clopidogrel.

Does clopidogrel cause joint pain?

Arthralgia and backache are also known to occur with its use. There have been case reports linking arthritis with the use of clopidogrel. We describe the case of a 64-year-old man who reported symptoms of fever and joint pains following initiation of therapy with clopidogrel. Acute-phase reactants were elevated.

What antacids can be taken with clopidogrel?

– Patients who use clopidogrel and need a medication to reduce stomach acid can use antacids and most H2 blockers such as Zantac (ranitidine), Pepcid (famotidine), Axid (nizatidine), but not Tagamet and Tagamet HB (cimetidine).

When should you not take clopidogrel?

If you have certain health conditions such as a peptic ulcer or bleeding disorder you should not take clopidogrel, unless advised by a specialist. You should use clopidogrel with caution if you have liver or kidney problems. Clopidogrel must not be given to anyone under 16 years old, unless under specialist advice.

Can I take clopidogrel every other day?

Conclusions: Long term dual anti-platelet therapy with aspirin 81 mg daily and clopidogrel 75 mg every other day beyond 12 months after PCI with DES may be a safe and efficacious cost-saving strategy to prevent VLST.